Thymosin Alpha 1 10mg

Thymosin Alpha 1 (Tα1) is a naturally occurring 28-amino-acid peptide cleaved from prothymosin alpha, a precursor linked to immune-system development and regulation. First characterised from thymus tissue, it is widely used in laboratory work on immune signalling, cellular defence, and inflammatory pathway control. Favourable stability and a broad immunological profile make it a frequent tool in both basic and applied peptide research.

Research focus and areas of interest

1. Adaptive immunity and T-cell biology

Tα1 is most often examined in adaptive-immunity models, where investigators look at T-lymphocyte maturation and function. Reported research endpoints include:

• T-cell differentiation and proliferative responses
• Support of MHC class I–related presentation pathways
• Cytokine balance under conditions that require controlled immune activation

These lines of work place Tα1 in studies of immune restoration concepts, host-defence signalling, and adaptive immune regulation.

2. Innate immunity and antimicrobial signalling

Parallel work explores innate immunity—the rapid first layer of host defence—including:

• Natural killer (NK) cell activity and immune surveillance
• Dendritic-cell behaviour and antigen presentation
• Interferon and related antimicrobial peptide responses

Activity across both innate and adaptive arms keeps Tα1 central to immune-priming and immunosurveillance experiments.

3. Inflammation and cytokine pathways

Researchers also map Tα1 against inflammatory cascades, including NF-κB-linked gene programmes and cytokines such as IL-2, IL-6, and TNF-α, plus checkpoints that balance pro- and anti-inflammatory signals. This supports work on chronic inflammation models and homeostatic immune control.

4. Stability and experimental handling

Tα1 is noted for useful biological stability, membrane access compatible with intracellular signalling studies, and compatibility with common laboratory delivery formats for in vitro and in vivo protocols.

5. Wider research contexts

Beyond core immunology, groups study cellular stress responses, multi-organ homeostatic regulation, and interfaces between immune modulation and tissue integrity.

Conclusion

Thymosin Alpha 1 remains a versatile research peptide for immune modulation, inflammation mapping, and cellular defence studies. Dual innate/adaptive relevance and a well-characterised sequence make it a practical reagent in modern peptide science.

For laboratory research use only. Not approved for human or veterinary applications. Sold by My UK Peptides strictly for scientific research and education.

Storage: Store lyophilised material at −20 °C, protected from light and moisture. After reconstitution, aliquot to avoid repeated freeze–thaw cycles. Reconstituted solutions are typically held at 4 °C for short laboratory use only.

Reconstitution: Reconstitute with bacteriostatic water under aseptic conditions unless the compound notes otherwise.

Technical information

• Synonyms: Tα1, Thymosin-α1, Thymalfasin
• Sequence (single-letter): SDKPESKETIEQEKQAGESQEAESAEAQG
• Molecular weight: ~3108.3 g/mol
• CAS: 62304-98-7
• PubChem CID: 16132252